CD79B - CD79b molecule Gene

Also Known as B29; IGB; AGM6; Igbeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 974

About CD79B

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,928,740-63,932,331 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 71 phenotypes. Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues.

Summary

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two Other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CD79B Products (4)

mRNA Protein Name
NM_000626.4 NP_000617.1 B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor
NM_001039933.3 NP_001035022.1 B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor
NM_001329050.2 NP_001315979.1 B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor
NM_021602.4 NP_067613.1 B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
14967045 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20696394 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
part of B cell receptor complex IDA
IDA: Inferred from direct assay
35981043 GOA
part of IgM B cell receptor complex IDA
IDA: Inferred from direct assay
35981043 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD79B Protein Structure

V-set

V-set: Immunoglobulin V-set domain (45 - 143)

ITAM

ITAM: Immunoreceptor tyrosine-based activation motif (194 - 213)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

B-cell antigen receptor complex-associated protein beta chain

  • B-cell-specific glycoprotein B29

CD79B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD79B P40259 SGTA Homo sapiens O43765
Validated Y2H
25910212
Intra
CD79B P40259 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
CD79B P40259 SGTA Homo sapiens O43765
Y2H Array
25910212
Intra
CD79B P40259 SGTA Homo sapiens O43765
Y2H Bait-Prey Pool
25910212
Intra
CD79B P40259 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
CD79B P40259 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
CD79B P40259 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD79B Proteins

Cat. No. Product Name Accession Purity
HY-P70541 CD79B Protein, Human (HEK293, His) P40259 (A29-D159) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70768 CD79B Protein, Human (Biotinylated, HEK293, His-Avi) P40259 (A29-D159) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75386 CD79 Protein, Human (HEK293, Flag-His) P11912-1 (L33-R143)&P40259-1 (A29-D159) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78415 CD79B Protein, Human (HEK293, His-Avi) P40259 (A29-D159) ≥ 95%, as determined by Bis-Tris PAGE.

CD79B Antibodies

Cat. No. Product Name Application Reactivity
HY-P81383 CD79b Antibody (YA1128) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P84298 CD79b Antibody (YA3995) ICC/IF, FC, ELISA Human
HY-P84298A CD79b Antibody (YA3995)(PBS only) ICC/IF, FC, ELISA Human
HY-P85008 CD79b Antibody (YA4700) ELISA, FC Human

Related Diseases

Diseases Alias
Agammaglobulinemia 6, Autosomal Recessive

  • Agammaglobulinemia 6

  • AGM6

  • Agammaglobulinemia, Autosomal Recessive, Due To Cd79b Defect

  • Agammaglobulinemia Autosomal Recessive Due To Cd79b Defect

  • Agammaglobulinemia, Type 6, Autosomal Recessive
Agammaglobulinemia, Non-Bruton Type

  • Autosomal Agammaglobulinemia
Agammaglobulinemia

  • Hypogammaglobulinemia

  • Ighm

  • Mu Heavy Chain Deficiency

  • Mu-Heavy Chain Disease

  • Mu-Hcd

  • Mu-Chain Disease
Mcd Diffuse Large B-Cell Lymphoma

  • Mcd Dlbcl

  • Doid:0081066
Bn2 Diffuse Large B-Cell Lymphoma

  • Bn2 Dlbcl

  • Doid:0081064
Testicular Lymphoma

  • Malignant Lymphoma Of Testis

  • Lymphoma Of The Testis
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Central Nervous System Hematologic Cancer

  • Cns Hematopoietic Tumor

  • Hematopoietic Neoplasm Of Central Nervous System

  • Central Nervous System Hematopoietic Neoplasm
Central Nervous System Lymphoma

  • Microglioma

  • Primary Cns Lymphoma

  • Cns Lymphoma

  • Primary Central Nervous System Lymphoma
Lambda 5 Deficiency
Agammaglobulinemia 4, Autosomal Recessive

  • Agammaglobulinemia 4

  • AGM4

  • Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

  • B Cell Linker Protein Deficiency

  • B-Cell Linker Protein Deficiency

  • Blnk Deficiency

  • Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

  • Agammaglobulinemia, Type 4, Autosomal Recessive
B-Cell Prolymphocytic Leukemia

  • B Cell Prolymphocytic Leukemia

  • Prolymphocytic Leukemia, B-Cell Type

  • B-Pll

  • Doid:0081041

  • Leukemia, Prolymphocytic, B-Cell

  • Pll- [Prolymphocytic Leukaemia]

  • Prolymphocytic Leukaemia

  • Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Cll/Sll

  • B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Icdo:9823/3

  • Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

  • Small Cell B-Cell Lymphoma
Primary Mediastinal B-Cell Lymphoma

  • Large Cell Lymphoma Of The Mediastinum

  • Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

  • Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Lymphoplasmacytic Lymphoma

  • Waldenstrom Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic

  • Waldenström Macroglobulinaemia

  • Waldenström Macroglobulinaemia Without Mention Of Remission

  • Idiopathic Macroglobulinaemia

  • Primary Macroglobulinaemia
Spleen Cancer

  • Spleen Neoplasm

  • Splenic Neoplasm

  • Splenic Neoplasms

  • Malignant Splenic Tumor

  • Malignant Tumour Of Spleen

  • Tumor Of Spleen

  • Malignant Neoplasm Of Spleen
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

  • Hgbl-Dh/Th

  • High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

  • High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Splenic Marginal Zone Lymphoma

  • Smzl

  • Splenic Marginal Zone B-Cell Lymphoma
Ezb Diffuse Large B-Cell Lymphoma

  • Ezb Dlbcl

  • Doid:0081065
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Richter'S Syndrome

  • Richter Syndrome

  • Richter Transformation
Marginal Zone B-Cell Lymphoma

  • Marginal Zone Lymphoma

  • Mzl

  • Mucosa-Associated Lymphoid Tissue Lymphoma
Eye Lymphoma

  • Malignant Lymphoma Of Eye

  • Lymphoma Of Eye
Cerebral Lymphoma

  • Primary Cerebral Lymphoma

  • Brain Primary Lymphoma

  • Primary Lymphoma Of Cerebrum
Ecthyma
Adult Lymphoma
Agammaglobulinemia, X-Linked

  • X-Linked Agammaglobulinemia

  • XLA

  • Bruton Type Agammaglobulinemia

  • Bruton'S Agammaglobulinemia

  • Bruton-Type Agammaglobulinemia

  • Agmx1

  • Imd1

  • Agammaglobulinemia, X-Linked 1

  • Btk-Deficiency

  • Agammaglobulinemia

  • Hypogammaglobulinemia

  • Agammaglobulinemia, X-Linked, Type 1

  • Immunodeficiency 1

  • Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

  • Bruton Disease

  • Bruton'S Agammaglobulinaemia

  • Bruton'S Sex-Linked Agammaglobulinemia

  • Bruton'S Type Agammaglobulinemia

  • Btk Deficiency

  • Agammaglobulinemia, Btk

  • Agammaglobulinemia, Bruton Tyrosine Kinase

  • Congenital Agammaglobulinemia

  • Immunodeficiency Type 1

  • X-Linked Agammaglobulinemia Type 1
Plasma Protein Metabolism Disease
Diffuse Large B-Cell Lymphoma Activated B-Cell Type

  • Dlbcl Abc Type
Waldenstroem'S Macroglobulinemia

  • Waldenstrom Macroglobulinemia

  • Macroglobulinemia Of Waldenstrom

  • Waldenström Macroglobulinemia

  • Lymphoplasmacytic Lymphoma With Igm Gammopathy

  • Lymphoplasmacytic Lymphoma

  • Waldenstrom'S Macroglobulinaemia

  • Waldenstrom'S Syndrome

  • Waldenstrom'S Macroglobulinemia

  • Wm

  • Waldenström'S Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Lymphoma, Mucosa-Associated Lymphoid Type

  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma
Mature B-Cell Neoplasm

  • Mature B-Cell Lymphocytic Neoplasm

  • Neoplasm Of Mature B-Cells

  • Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132253 Polatuzumab vedotin Inhibitor 99.37% Unkown

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99042 Polatuzumab 99.69% Phase 3
HY-P991671 Anafiltamig Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132253A Polatuzumab vedotin (solution) Inhibitor 99.40% Unkown
HY-163295 BTK degrader-1 Degrader 99.40% Unkown
HY-157763 Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 Degrader / Unkown
HY-P11779 Ac-RKAA-PABC-MMAE Inhibitor / Unkown
HY-RS02268 CD79B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17825 Cd79b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24293 Cd79b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99656 Iladatuzumab 96.97% Unkown
HY-P991086 MGD010 Inhibitor 99.06% Unkown
HY-P991804 Anti-Mouse CD79b Antibody (HM79b) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CD79B VGNC VGNC:27047
Mus musculus CD79B MGD MGI:96431
Canis familiaris CD79B VGNC VGNC:38974
Macaca mulatta CD79B VGNC VGNC:99136
Rattus norvegicus CD79B RGD RGD:620012
Others CD79B NCBI